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Rabbit polyclonal antibody to HIF~1α (K377)

Western blot (WB) analysis of HIF~1α (K377) pAb at 1:1000 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:A549 whole cell lysate(40ug) Lane3:EC9706 whole cell lysate(40ug)

Rabbit polyclonal antibody to HIF~1α (K377)

货号：
53882
别名：
Hypoxia~inducible factor 1~alpha; HIF~1~alpha; HIF1~alpha; ARNT~interacting protein; Basic~helix~loop~helix~PAS protein MOP1; Class E basic helix~loop~helix protein 78; bHLHe78; Member of PAS protein 1; PAS domain~containing protein 8; HIF1A; BHLHE78, MOP1
产品上架时间：
2024-01-01
应用：
WB IP
反应种属：
Human,Rat,Mouse
抗体类型：
Primary antibody
Swissprot：
Q16665
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1180

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Rabbit polyclonal antibody to HIF~1α (K377)

Description
Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia~inducible factors, including HIF~1α, Arnt 1 (also designated HIF~1β), EPAS~1 (also designated HIF~2α) and HIF~3α, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia~inducible factors are members of the Per~Arnt~Sim (PAS) domain transcription factor family. In response to hypoxia, HIF~1α is upregulated and forms a heterodimer with Arnt 1 to form the HIF~1 complex. The HIF~1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia~inducible genes, thereby activating transcription.

Description

Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia~inducible factors, including HIF~1α, Arnt 1 (also designated HIF~1β), EPAS~1 (also designated HIF~2α) and HIF~3α, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia~inducible factors are members of the Per~Arnt~Sim (PAS) domain transcription factor family. In response to hypoxia, HIF~1α is upregulated and forms a heterodimer with Arnt 1 to form the HIF~1 complex. The HIF~1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia~inducible genes, thereby activating transcription.

Specification
Aliases	Hypoxia~inducible factor 1~alpha; HIF~1~alpha; HIF1~alpha; ARNT~interacting protein; Basic~helix~loop~helix~PAS protein MOP1; Class E basic helix~loop~helix protein 78; bHLHe78; Member of PAS protein 1; PAS domain~containing protein 8; HIF1A; BHLHE78, MOP1
Swissprot	Q16665
clone	8A1E9
WB Predicted band size	~120kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Rat,Mouse
Immunogen	Synthetic peptide, corresponding to Human HIF~1α.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2