Rabbit polyclonal antibody to BMP~5 (L163)

Growth factor of the TGF~beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis.Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2.In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes.Can also signal through non~canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation.