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Rabbit polyclonal antibody to eIF4E (T203)

Western blot (WB) analysis of eIF4E (T203) pAb at 1:1000 dilution Lane1:Hela whole cell lysate(40ug) Lane2:SGC7901 whole cell lysate(40ug) Lane3:The Spleen tissue lysate of Rat(40ug) Lane4:3T3~L1 whole cell lysate(40ug) Lane5:BV2 whole cell lysate(40ug)

Rabbit polyclonal antibody to eIF4E (T203)

货号：
53861
别名：
eIF4E ( phospho S209 ); eIF~4E; eIF4E; mRNA cap~binding protein; eIF~4F 25 kDa subunit; EIF4E; 1977; EIF4E; 133440; P06730; CBP; EIF4EL1; EIF4F; MGC111573;
产品上架时间：
2024-01-01
应用：
WB IHC IP
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P06730
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1180

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Rabbit polyclonal antibody to eIF4E (T203)

Description
eIF4E, a protein modulates translation of maternal mRNAs in early embryos before the onset of zygotic transcription. eIF4E also influences the overall rate of translation. eIF4E binds to the 7 methyl GTP cap structure of eukaryotic mRNAs. Phosphorylation of eIF4E on serine 209 regulates the affinity of this protein for the 7 methyl GTP cap and/or RNA. Phosphorylation also enhances the interaction of eIF4E with eIF4G, which form a complex known as eIF4F. eIF4E phosphorylation is correlated with increased translational rate in a number of cell types. Several kinases are currently being investigated as potential regulators of eIF4E including PKC and/or the MAP kinase activated Mnk.

Description

eIF4E, a protein modulates translation of maternal mRNAs in early embryos before the onset of zygotic transcription. eIF4E also influences the overall rate of translation. eIF4E binds to the 7 methyl GTP cap structure of eukaryotic mRNAs. Phosphorylation of eIF4E on serine 209 regulates the affinity of this protein for the 7 methyl GTP cap and/or RNA. Phosphorylation also enhances the interaction of eIF4E with eIF4G, which form a complex known as eIF4F. eIF4E phosphorylation is correlated with increased translational rate in a number of cell types. Several kinases are currently being investigated as potential regulators of eIF4E including PKC and/or the MAP kinase activated Mnk.

Specification
Aliases	eIF4E ( phospho S209 ); eIF~4E; eIF4E; mRNA cap~binding protein; eIF~4F 25 kDa subunit; EIF4E; 1977; EIF4E; 133440; P06730; CBP; EIF4EL1; EIF4F; MGC111573;
Swissprot	P06730
clone	6C7B7
WB Predicted band size	~25kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide, corresponding to amino acids 171~210 of Human eIF4E.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2