Rabbit polyclonal antibody to Plakophilin 2 (P663)

Plakophilins 1, 2, 3 and 4 (PKP1~4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1~4 contain arm~repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell~cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.