Rabbit polyclonal antibody to ME3 (R576)

ME3 (malic enzyme 3), also known as NADP~ME (NADP~dependent malic enzyme, mitochondrial), is a 604 amino acid protein of the mitochondrial matrix that catalyzes the conversion of (S)~malate and NADP+ to pyruvate, carbon dioxide and NADPH. A member of the malic enzymes family, ME3 utilizes manganese and magnesium as cofactors and is expressed in tissues that divide at a low rate. The gene encoding ME3 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange~Nielsen syndrome, Jacobsen syndrome, Niemann~Pick disease, hereditary angioedema and Smith~Lemli~Opitz syndrome are associated with defects in genes that maps to chromosome 11.