Rabbit polyclonal antibody to FBP3 (R241)

Activation of FUSE, the far~upstream element, is required for the proper expression of the mammalian gene c~Myc in undifferentiated cells. The binding of FBP (FUSE~binding protein) to FUSE is necessary for c~Myc expression, indicating that FBP functions as a growth~dependent regulator of c~Myc expression. Isolated from proliferating HL60 cells, FBP, FBP2, and FBP3 comprise a family of single~stranded DNA~binding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA~binding domain and show significant homology in their carboxylterminal activation domains. Expression of FBP is detected in undifferentiated cells and is substantially decreased following cellular differentiation.