Rabbit polyclonal antibody to Calponin 2 (D156)

Calponin, a 34 kDa protein, regulates smooth muscle cell contraction and is a marker of smooth muscle cell differentiation. Calponin, an actin~ and tropomyosin~binding protein, is characterized as an inhibitory factor of smooth~muscle actomyosin activity. Calponin is implicated in the regulation of smooth muscle contraction through its interaction with F~actin and inhibition of the actin~activated MgATPase activity of phosphorylated myosin.Both properties are lost following phosphorylation (primarily at serine 175) by protein kinase C or calmodulin~dependent protein kinase II. The three forms of Calponin, Calponin 1 (basic Calponin), Calponin 2 (neutral Calponin), and Calponin 3 (acidic Calponin) are found in smooth muscle tissue. Additionally, Calponin 2 is found in heart muscle tissue and Calponin 3 is found in the brain.