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Rabbit polyclonal antibody to Histone H2A.X (S130)

Western blot (WB) analysis of Histone H2A.X (S130) pAb at 1:500 dilution Lane1:HepG2 whole cell lysate(40ug) Lane2:A549 whole cell lysate(40ug) Lane3:3T3~L1 whole cell lysate(40ug) Lane4:H9C2 whole cell lysate(40ug)

Rabbit polyclonal antibody to Histone H2A.X (S130)

货号：
53774
别名：
Histone H2AX; H2a/x; Histone H2A.X; H2AFX; H2AX;
产品上架时间：
2024-01-01
应用：
WB IHC IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P16104
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to Histone H2A.X (S130)

Description
H2A.X is a member of the histone H2A family, 1 of 5 families of histone proteins involved in nucleosomal organization of chromatin. H2A.X is synthesised in G1 as well as S phase and is known to be important for recombination between immunoglobulin switch regions. A very early step in the response of mammalian cells to DNA double~strand breaks is the phosphorylation of histone H2A.X at serine 139 at the sites of DNA damage. There is a predicted acetylation at residue 1 and ubiquitination at reside 119. Phosphorylated H2A.X promotes DNA repair and maintains genomic stability.

Description

H2A.X is a member of the histone H2A family, 1 of 5 families of histone proteins involved in nucleosomal organization of chromatin. H2A.X is synthesised in G1 as well as S phase and is known to be important for recombination between immunoglobulin switch regions. A very early step in the response of mammalian cells to DNA double~strand breaks is the phosphorylation of histone H2A.X at serine 139 at the sites of DNA damage. There is a predicted acetylation at residue 1 and ubiquitination at reside 119. Phosphorylated H2A.X promotes DNA repair and maintains genomic stability.

Specification
Aliases	Histone H2AX; H2a/x; Histone H2A.X; H2AFX; H2AX;
Swissprot	P16104
clone	9F6G4
WB Predicted band size	~15kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide, corresponding to amino acids 100~150 of Human Histone H2A.X.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2