Rabbit polyclonal antibody to Synphilin~1 (R846)

Synphilin~1 (α~synuclein interacting protein, SNCAIP) is a 919 amino acid protein that associates with α synuclein and promotes the formation of cytosolic inclusions in neuronal cells. The synuclein family members, including α~synuclein and β~synuclein, are predominantly expressed in the brain, where they influence synaptic regulation and neuronal plasticity. Synphilin~1 contains modular protein domains, such as ankyrin~like repeats and a coiled~coil domain.While both α~synuclein and synphilin~1 are coexpressed in Lewy bodies of patients with Parkinson’s disease, only mutations in the gene for α~synuclein have been determined to confer pathogenicity.