Rabbit polyclonal antibody to GCSm~γ (V91)

Gamma~glutamylcysteine synthetase (γ~GCS) is the rate limiting enzyme for glutathione (L~γ~glutamyl~L~cysteinylglycine, GSH) synthesis. GSH is ubiquitous in mammalian cells as a vital intra~ and extracellular protective antioxidant. γ~GCS is a heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic ntioxidants, heat shock, oxidants and cytokines. The human γ~GCS gene encoding the 367 amino acid catalytic subunit maps to chromosome 6p12. The human γ~GCS gene encoding the regulatory subunit maps to chromosome 1p22~p21. The two subunits of γ~GCS form a heterodimeric zinc metalloprotein that gains activity through formation of a reversible disulfide bond.