Rabbit polyclonal antibody to CTPS (K109)

CTPS (cytidine~5~prime~triphosphate synthase) is a 591 amino acid protein that contains one glutamine amidotransferase type~1 domain and is involved in pyrimidine metabolism. CTPS catalyzes the ATP~dependent conversion of UTP to CTP, a rate~limiting reaction that requires either ammonia or L~glutamine as a nitrogen source. Via its catalytic activity, CTPS plays an important role in the synthesis of nucleic acids and is crucial for proper cell growth and development. The function of CTPS is regulated by a variety of mechanisms, including phosphorylation by protein kinase C (PKC), an event that can either stimulate or inhibit CTPS activity. The gene encoding CTPS is located in a region on chromosome 1 that is often associated with the progression of several tumor types, suggesting a possible role for CTPS in tumorigenesis.