Rabbit polyclonal antibody to EDG~4 (L310)

The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine~1~phosphate (SPP) and lysophosphatidic acid (LPA). EDG~1, EDG~3, EDG~5 (also designated H218 and AGR16) and EDG~8 bind SPP with high~affinity. EDG~6 is a low~affinity receptor for SPP. LPA preferentially binds to EDG~2, EDG~4 and EDG~7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG~1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG~2 is expressed in brain, especially in white matter tract regions, while EDG~3 is expressed in cardiovascular tissue and in cerebellum. EDG~4 is highly expressed on leukocytes and brain, and EDG~5 has wide tissue distribution, including cardiovascular tissue and brain. Expressed in lymphoid and hematopoietic tissues and in lung, EDG~6 signals through Gi/o proteins, which activate growth related pathways.