Rabbit polyclonal antibody to Frizzled~7 (Y87)

The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled, as well as several secreted mammalian frizzled~related proteins: FRP~1 (also designated SARP2), FRP~2 (also designated SARP1), FRP~3, FRP~4 and SARP3 (also designated FRP~5), have been identified. The frizzled proteins contain seven transmembrane domains, a cysteine~rich domain in the extracellular region and a carboxy terminal Ser/Thr~xxx~Val motif. They function as receptors for Wnt. frizzled~7 has a Lys~Thr~X~X~X~Trp motif which is involved in the activation of the Wnt/beta~catenin signaling pathway. frizzled~7 is an integral membrane protein showing a high expression in adult skeletal muscle, fetal kidney, fetal lung, adult heart, brain and placenta. It is specifically expressed in squamous cell esophageal carcinomas.