Rabbit polyclonal antibody to mGluR~5 (K56)

The mGluR proteins (metabotropic glutamate receptors) are members of the G protein~coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic glutamate receptors). The eight currently known mGluR proteins are mediated by two G proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR~1 and mGluR~5 are mediated by a G protein that activates a phosphatidylinositolcalcium second messenger system and generates a calcium~activated chloride current. The remainder of the eight subtypes of mGluR have an activity mediated by a G protein that inhibits adenylate cyclase activity. mGluR~3, which may interact with GRASP, acts as a receptor for glutamate.