Rabbit polyclonal antibody to Frizzled~8

Receptor for Wnt proteins. Component of the Wnt~Fzd~LRP5~LRP6 complex that triggers beta~catenin signaling through inducing aggregation of receptor~ligand complexes into ribosome~sized signalosomes. The beta~catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK~3 kinase, nuclear accumulation of beta~catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt~mediated inactivation of GSK~3 kinase. Both pathways seem to involve interactions with G~proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.