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Western blot (WB) analysis of PRPF19 polyclonal antibody at 1:500 dilution Lane1:The Brain tissue lysate of Rat(20ug) Lane2:The Brain tissue lysate of Mouse(20ug) Lane3:MCF~7 whole cell lysate(10ug) Lane4:Hela whole cell lysate(10ug)

Rabbit polyclonal antibody to PRPF19

货号：
53745
别名：
Pre~mRNA~processing factor 19; Nuclear matrix protein 200; PRP19/PSO4 homolog; hPso4; RING~type E3 ubiquitin transferase PRP19; Senescence evasion factor; PRPF19I; NMP200; PRP19; SNEV
产品上架时间：
2024-01-01
应用：
WB
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q9UMS4
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1180

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Rabbit polyclonal antibody to PRPF19

Description
The spliceosome, the 0gigantic molecular machine that performs pre~mRNA splicing in eukaryotes, contains over 200 different proteins and five RNA molecules (U1, U2, U4, U5 and U6). Pre~mRNA splicing is essential to remove internal non~coding regions of pre~mRNA (introns) and to join the remaining segments (exons) into mRNA before translation. The PRP19~associated complex is required for stable association of U5 and U6 with the spliceosome after U4 is released. Changes within the spliceosome upon binding of the PRP19~associated complex include remodeling of the U6/5‘ splice site interaction and destabilization of Lsm proteins to allow further interaction of U6 with the intron sequence.

Description

The spliceosome, the 0gigantic molecular machine that performs pre~mRNA splicing in eukaryotes, contains over 200 different proteins and five RNA molecules (U1, U2, U4, U5 and U6). Pre~mRNA splicing is essential to remove internal non~coding regions of pre~mRNA (introns) and to join the remaining segments (exons) into mRNA before translation. The PRP19~associated complex is required for stable association of U5 and U6 with the spliceosome after U4 is released. Changes within the spliceosome upon binding of the PRP19~associated complex include remodeling of the U6/5‘ splice site interaction and destabilization of Lsm proteins to allow further interaction of U6 with the intron sequence.

Specification
Aliases	Pre~mRNA~processing factor 19; Nuclear matrix protein 200; PRP19/PSO4 homolog; hPso4; RING~type E3 ubiquitin transferase PRP19; Senescence evasion factor; PRPF19I; NMP200; PRP19; SNEV
Swissprot	Q9UMS4
clone	4D8E4
WB Predicted band size	~55kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide, corresponding Human PRPF19.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2