Rabbit polyclonal antibody to Frizzled~10 (FZD10)

Receptor for Wnt proteins. Functions in the canonical Wnt/beta~catenin signaling pathway (By similarity). The canonical Wnt/beta~catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK~3 kinase, nuclear accumulation of beta~catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt~mediated inactivation of GSK~3 kinase. Both pathways seem to involve interactions with G~proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).