Rabbit polyclonal antibody to CRF~RI (H177)

A high affinity CRF binding protein, designated CRF~BP, has been discovered in postmortem brain samples from AD patients. CRF~BP serves to bind and inactivate CRF, reducing the pool of “free CRF” available to bind CRFRs. Two CRF receptors, designated CRF~RI and CFR~RII, exhibit distinct brain localizations.Two forms of CFR~RII, designated CFR~RIIα and CFR~RIIβ, result from alternative mRNA splicing. Urocortin, an additional member of the CRF family, shares 63% sequence identity with urotensin and 45% sequence identity with CRF. Urocortin specifically binds to and activates CRF~RI and CRF~RII, but binds to CRF~RII more efficiently than CRF, suggesting that it may be the true, high affinity ligand for the CRF receptor type II.