Rabbit polyclonal antibody to ADORA3 (E318)

Adenosine is involved in a variety of processes, including the synthesis of urea, the anti~inflammatory response and the inhibition of protein synthesis The adenosine receptors, including adenosine A1~R, adenosine A2A~R, adenosine A2B~R and adenosine A3~R, are integral membrane proteins that are members of the G protein~coupled receptor family. The A1~R protein mediates ureagenesis in a partially calcium~dependent manner. Adenosine is known to mediate coronary vasodilation via the A2A~R receptor. Collagen synthesis and total protein synthesis are inhibited in certain cells by adenosine, acting via the A2B receptors. Activation of the A3~R receptor inhibits the induction of the cytokine TNFα and blocks the endotoxin CD14 receptor signal transduction pathway.