Rabbit polyclonal antibody to RPL10 (F34)

The c~Jun protein is a major component of the transcription factor AP~1, originally shown to mediate phorbol ester tumor promoter (TPA)~induced expression of responsive genes through the TPA~response element (TRE). The Jun proteins form homo~ and heterodimers which bind the TRE, while Fos proteins are active only as heterodimers with any of the Jun proteins. Fos/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. A distant member of the MAP kinase family, designated c~Jun NH2~terminal kinase (JNK1) functions to regulate c~Jun by phosphorylation at the amino terminal serine regulatory sites, Ser 63 and Ser 73). RPL10 has been described as a transcription factor that can function to bind DNA directly or alternatively can interact with c~Jun to inhibit transactivation of AP~1 promoter driven reporter vectors by Jun~Jun homodimers. RPL10 is highly conserved throughout eukaryotic evolution and is apparently a member of a multi~gene family.