Rabbit polyclonal antibody to ABL1 (E883)

The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A~MuLV). The major translational product of c~Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90~95% of chronic myelocytic leukemia (CML), 20~25% of adult acute lymphoblastic leukemia (ALL) and 2~5% of pediatric ALL. In these leukemias the c~Abl proto~oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c~Abl mRNA encoding activated Abl protein~tyrosine kinase. The Bcr gene has been shown to encode a GTPase~activating protein (GAP) specific for the Ras~related GTP~binding protein, p21rac.