Rabbit polyclonal antibody to ZBP~89 (E84)

ZBP~89, also known as BFCOL1, BERF1 and ZNF 148, is a zinc finger transcription factor that is universally expressed. ZBP~89, a Kruppel~like repressor protein, is the silencer element binding factor for Vimentin. ZBP~89 has been shown to bind to GC~rich DNA elements in promoters for gastrin, ornithine decarboxylase and the cyclin~dependent kinase inhibitor p21 (also designated Cip1 or WAF1). ZBP~89 expression is induced by trans~retinoic acid or butyrate, which also induces terminal differentiation of colon cancer cells. ZBP~89 cooperates with histone acetyltransferase coactivator p300 in the regulation of p21, a cyclin~dependent kinase inhibitor whose associated gene is a target gene of p53. ZBP~89 also regulates cell proliferation, in part, through its ability to directly bind the p53 protein and retard its nuclear export. Elevated levels of ZBP~89 induce growth arrest and apoptosis in human gastrointestinal cells.