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Rabbit polyclonal antibody to MINK1 (R406)

Western blot (WB) analysis of MINK1 (R406) polyclonal antibody at 1:500 dilution Lane1:H1792 whole cell lysate(40ug) Lane2:Panc1 whole cell lysate(40ug) Lane3:The Testis tissue lysate of Rat(40ug)

Rabbit polyclonal antibody to MINK1 (R406)

货号：
53699
别名：
Misshapen~like kinase 1; GCK family kinase MiNK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Misshapen/NIK~related kinase; Mitogen~activated protein kinase kinase kinase kinase 6; MINK1; B55; MAP4K6; MINK; YSK2; ZC3
产品上架时间：
2024-01-01
应用：
WB
反应种属：
Human,Rat
抗体类型：
Primary antibody
Swissprot：
Q8N4C8
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to MINK1 (R406)

Description
Serine/threonine kinase which acts as a negative regulator of Ras~related Rap2~mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress~activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell~matrix adhesion, cell~cell adhesion and cell migration.

Description

Serine/threonine kinase which acts as a negative regulator of Ras~related Rap2~mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress~activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell~matrix adhesion, cell~cell adhesion and cell migration.

Specification
Aliases	Misshapen~like kinase 1; GCK family kinase MiNK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Misshapen/NIK~related kinase; Mitogen~activated protein kinase kinase kinase kinase 6; MINK1; B55; MAP4K6; MINK; YSK2; ZC3
Swissprot	Q8N4C8
clone	2B6F4
WB Predicted band size	~180kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Rat
Immunogen	Synthetic peptide, corresponding to amino acids 376~436 of Human MINK1.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2