Rabbit polyclonal antibody to Myc (K422)

c~Myc~, N~Myc~ and L~Myc~encoded proteins function in cell proliferation, differentiation and neoplastic disease. Myc proteins are nuclear proteins with relatively short half lives. Amplification of the c~Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N~Myc gene has been found amplified in neuroblastomas. The presence of three sequence motifs in the c~Myc COOH terminus, including the leucine zipper, the helix~loop~helix and a basic region provided initial evidence for a sequence~specific binding function.