Rabbit polyclonal antibody to LI~cadherin (T363)

The cadherins are a family of Ca++~dependent adhesion molecules that function to mediate cell~cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including catenin β, to regulate cadherin function. LI~cadherin (for liver~intestine~cadherin) expression is restricted to liver and intestine tissues and is specifically localized to the basolateral domain of hepatocytes and enterocytes.