Rabbit polyclonal antibody to AIM2 (A78)

Interferon~inducible protein AIM2 (absent in melanoma 2) is a 343 amino acid protein belonging to the HIN~200 family. Induced by IFN~γ, AIM2 is thought to act as a tumor suppressor by repressing NFκB transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN~200 domain. The DAPIN domain is composed mostly of α~helixes and is a protein~protein interaction domain capable of binding other DAPIN domains. The HIN~200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of caspase~1. AIM2 is present as a homodimer and is expressed highly in small intestine, testis, peripheral blood leukocytes and spleen. Defects in AIM2 are believed to be a cause of microsatellite unstable colon cancers.