Rabbit polyclonal antibody to SR~4 (D47)

Serotonin (also designated 5~hydroxytryptamine or 5~HT) is a molecule that functions as a neurotransmitter, a hormone and a mitogen, and it is predominantly expressed in the gut, platelets and central nervous system (CNS). In the CNS, serotonin modulates several processes, including anxiety, sleep, appetite, behavior and drug abuse. In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5~HT receptors or alternatively SR receptors. SR~3 is a ligand~gated ion channel, whereas all other known serotonin receptor subtypes are G protein~coupled receptors. The gene which encodes SR~3 maps to human chromosome 11q23.1~q23.2. SR~4 mediates widespread effects in central and peripheral nervous systems. The gene which encodes SR~4 maps to human chromosome 5q31~q33. SR~7 belongs to the superfamily of G protein~coupled receptors.