Rabbit polyclonal antibody to MRCKβ (F1665)

Protein kinases comprise a large group of encoded factors that regulate cellular processes by catalyzing the transfer of a phosphate group to a hydroxyl acceptor in serine, threonine or tyrosine residues. Myotonic dystrophy kinaserelated Cdc42~binding (DMPK~like) kinases~α and β (MRCK~α, β) contain a cysteine~rich motif and a putative pleckstrin homology domain. MRCKs can phosphorylate nonmuscle Myosin light chain and influences Actin~Myosin contractility. MRCK~α can phosphorylate and activate LIM kinases downstream of Cdc42, which leads to inactivation of ADF/Cofilin and to Actin cytoskeletal reorganization. MRCK~α can also influence neurite outgrowth promoted by Cdc42 and Rac.