Rabbit polyclonal antibody to COPS5 / JAB1 (K191)

Genes belonging to the Jun and Fos oncogene families encode nuclear proteins that are found to be associated with a number of transcriptional complexes. The c~Jun protein is a major component of the transcription factor AP~1, originally shown to mediate phorbol ester tumor promoter (TPA)~induced expression of responsive genes through the TPA~response element (TRE). The Jun proteins form homo~ and heterodimers which bind the TRE, but the Fos proteins are active only as heterodimers with any of the Jun proteins. Fos/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. Ha~Ras augments c~Jun activity and stimulates phosphorylation of its activation domain. The coactivator of Jun, designated JAB1 (for Junactivation