Rabbit polyclonal antibody to Ksr2 (I694)

Kinase suppressor of Ras (Ksr) and MAP kinase kinase kinase (MEKK3) are integral members of the MAP kinase pathway. Ksr is a conserved protein that positively regulates Ras signaling and may function as a scaffold for Raf, MEK and ERK. There are two types of Ksr proteins: Ksr~1 and Ksr~2. Ksr~2 plays a key role in Ras~mediated signaling during germline meiotic progression and functions redundantly with Ksr~1 during the development of the excretory system pathway, hermaphrodite vulva, and male spicules. Ksr~2 also functions as a negative regulator of the MEKK3~mediated activation of the MAP kinase pathways (specifically ERK and JNK) and of the NF˚B pathways, and it simultaneously inhibits MEKK3~mediated Il~8 production.