Rabbit polyclonal antibody to GPR68 (R214)

G protein~coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus~response pathways. G protein~coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR68 (G protein~coupled receptor 68), also known as OGR1 (ovarian cancer G~protein coupled receptor 1), is a 365 amino acid multi~pass membrane protein that is expressed in testis, spleen, lung, brain and placenta. Existing as a member of the G protein~coupled receptor family, GPR68 functions as a high affinity receptor for sphingosylphosphorylcholine and is coupled to G proteins that enhance phosphoinositide hydrolysis.