Rabbit polyclonal antibody to PBF (R151)

PBF, also known as PTTG1IP (pituitary tumor~transforming 1 interacting protein), is a 180 amino acid single~pass type I membrane protein that localizes both the cytoplasm and the nucleus and contains a coiled~coil domain. Expressed ubiquitously, PBF interacts with PTTG and is thought to facilitate the nuclear translocation of PTTG, thereby allowing the PTTG~dependent transcriptional activation of fibroblast growth factor (FGF). The gene encoding PBF maps to human chromosome 21, which houses approximately 300 genes and comprises nearly 1.5% of the human genome. Chromosome 21~associated disorders include Alzheimer’s disease, amyotrophic lateral sclerosis and, most notably, Down syndrome (also known as trisomy 21).