Rabbit polyclonal antibody to MEK~4 (K350)

The prototype member of this family, designated MAP kinase kinase, or MEK~1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr~Glu~Tyr motif of ERK. A second MEK family member, MEK~2, resembles MEK~1 in its substrate specificity. MEK~3 (or MKK~3) functions to activate p38 MAP kinase, and MEK~4 (also called SEK1 or MKK~4) activates both p38 and JNK MAP kinases. MEK~5 appears to specifically phosphorylate ERK 5, whereas MEK~6 phosphorylates p38 and p38β. MEK~7 (or MKK~7) phosphorylates and activates the JNK signal transduction pathway.