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Rabbit polyclonal antibody to Rad50 (A708)

Western blot (WB) analysis of Rad50 (A708) polyclonal antibody at 1:500 dilution Lane1:786~O whole cell lysate(40ug) Lane2:U~87MG whole cell lysate(40ug) Lane3:SGC~7901 whole cell lysate(40ug) Lane4:SK~OVCAR3 whole cell lysate(40ug) Lane5:The Testis tissue lysate of Mouse(40ug) Lane6:The Testis tissue lysate of Rat(40ug) Lane7:C6 whole cell lysate(40ug)

Rabbit polyclonal antibody to Rad50 (A708)

货号：
53605
别名：
DNA repair protein RAD50; hRAD50; RAD50
产品上架时间：
2024-01-01
应用：
WB IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q92878
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥2180

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Rabbit polyclonal antibody to Rad50 (A708)

Description
Rad52 family members (Rad50, Rad51B/C/D, Rad52, Rad54, MRE11) mediate DNA double~strand break repair (DSBR) for DNA damage that otherwise could cause cell death, mutation or neoplastic transformation. Rad51 (RECA, BRCC5) interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of Rad51. Rad52 forms a heptameric ring that binds single~stranded DNA ends and catalyzes DNA~DNA interaction necessary for the annealing of complementary strands.

Description

Rad52 family members (Rad50, Rad51B/C/D, Rad52, Rad54, MRE11) mediate DNA double~strand break repair (DSBR) for DNA damage that otherwise could cause cell death, mutation or neoplastic transformation. Rad51 (RECA, BRCC5) interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of Rad51. Rad52 forms a heptameric ring that binds single~stranded DNA ends and catalyzes DNA~DNA interaction necessary for the annealing of complementary strands.

Specification
Aliases	DNA repair protein RAD50; hRAD50; RAD50
Swissprot	Q92878
clone	4B5C5
WB Predicted band size	~170kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide, corresponding to amino acids 670~722 of Human Rad50.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2