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Rabbit polyclonal antibody to CYP3A4/5 (F386)

Western blot (WB) analysis of CYP3A4/5 (F386) pAb at 1:500 dilution Lane1:HepG2 whole cell lysate(40ug) Lane2:A549 whole cell lysate(40ug) Lane3:The Liver tissue lysate of Rat(40ug) Lane4:The Liver tissue lysate of Mouse(40ug)

Rabbit polyclonal antibody to CYP3A4/5 (F386)

货号：
53591
别名：
Cytochrome P450 3A4; 1,8~cineole 2~exo~monooxygenase; Albendazole monooxygenase; Albendazole sulfoxidase; CYPIIIA3; CYPIIIA4; Cytochrome P450 3A3; Cytochrome P450 HLp; Cytochrome P450 NF~25; Cytochrome P450~PCN1; Nifedipine oxidase; Quinine 3~monooxygenase; Taurochenodeoxycholate 6~alpha~hydroxylase; CYP3A4; CYP3A3; Cytochrome P450 3A5; CYPIIIA5; Cytochrome P450 HLp2; Cytochrome P450~PCN3; CYP3A5
产品上架时间：
2024-01-01
应用：
WB IHC IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P08684/P20815
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to CYP3A4/5 (F386)

Description
Cytochrome P450 3A (CYP3A) genes encode monooxygenases—enzymes which catalyze drug metabolism and the synthesis of cholesterol, steroids and other lipids. CYP3A, the most abundant p450 enzyme in human liver, is responsible for the metabolism of more than 50% of all clinical drugs. CYP3A family members localize in organs that associate with drug disposition, including the liver, gastrointestinal tract and kidney. The CYP3A cluster maps to gene locus 7q21.3~q22.1 and consists of four genes (CYP3A4, CYP3A5, CYP3A7 andCYP3A43) and two pseudogenes (CYP3A5P1 and CYP3A5P2). CYP3A4 is abundant in the endoplasmic reticulum of liver cells and upper intestinal enterocytes. CYP3A4 expression is inducible by glucocorticoids pharmacological agents.

Description

Cytochrome P450 3A (CYP3A) genes encode monooxygenases—enzymes which catalyze drug metabolism and the synthesis of cholesterol, steroids and other lipids. CYP3A, the most abundant p450 enzyme in human liver, is responsible for the metabolism of more than 50% of all clinical drugs. CYP3A family members localize in organs that associate with drug disposition, including the liver, gastrointestinal tract and kidney. The CYP3A cluster maps to gene locus 7q21.3~q22.1 and consists of four genes (CYP3A4, CYP3A5, CYP3A7 andCYP3A43) and two pseudogenes (CYP3A5P1 and CYP3A5P2). CYP3A4 is abundant in the endoplasmic reticulum of liver cells and upper intestinal enterocytes. CYP3A4 expression is inducible by glucocorticoids pharmacological agents.

Specification
Aliases	Cytochrome P450 3A4; 1,8~cineole 2~exo~monooxygenase; Albendazole monooxygenase; Albendazole sulfoxidase; CYPIIIA3; CYPIIIA4; Cytochrome P450 3A3; Cytochrome P450 HLp; Cytochrome P450 NF~25; Cytochrome P450~PCN1; Nifedipine oxidase; Quinine 3~monooxygenase; Taurochenodeoxycholate 6~alpha~hydroxylase; CYP3A4; CYP3A3; Cytochrome P450 3A5; CYPIIIA5; Cytochrome P450 HLp2; Cytochrome P450~PCN3; CYP3A5
Swissprot	P08684/P20815
clone	6H5F6
WB Predicted band size	~57kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide, corresponding to amino acids 351~400 of Human CYP3A4.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2