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Rabbit polyclonal antibody to CYP17A1 (N249)

Western blot (WB) analysis of CYP17A1 (N249) pAb at 1:500 dilution Lane1:MCF~7 whole cell lysate(40ug) Lane2:A2780 whole cell lysate(40ug) Lane3:PC3 whole cell lysate(40ug) Lane4:HEK293T whole cell lysate(40ug)

Rabbit polyclonal antibody to CYP17A1 (N249)

货号：
53589
别名：
Steroid 17~alpha~hydroxylase/17,20 lyase; 17~alpha~hydroxyprogesterone aldolase; CYPXVII; Cytochrome P450 17A1; Cytochrome P450~C17; Cytochrome P450c17; Steroid 17~alpha~monooxygenase; CYP17A1; CYP17; S17AH
产品上架时间：
2024-01-01
应用：
WB IHC IF
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P05093
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1180

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Rabbit polyclonal antibody to CYP17A1 (N249)

Description
CYP17A (17α~hydroxylase/17,20~lyase) is important for the conversion of pregnenolone and progesterone to dehydroepiandrosterone (DHEA) and androstenedione. In this process, it catalyzes both the 17α~hydroxylation and the 17,20~lyase reaction.CYP17A1 is crucial during sexual development, both during fetal development and during puberty, and is intracellularly regulated by cAMP levels. Defects in the CYP17A1 gene, which encodes for the protein, may cause adrenal hyperplasia type V (AH~V) which is characterized by hypokalemia and hypertension.Male patients affected by AH~V do not undergo normal sexual differentiation and develop female external genitalia and do not undergo pubertal develoment.

Description

CYP17A (17α~hydroxylase/17,20~lyase) is important for the conversion of pregnenolone and progesterone to dehydroepiandrosterone (DHEA) and androstenedione. In this process, it catalyzes both the 17α~hydroxylation and the 17,20~lyase reaction.CYP17A1 is crucial during sexual development, both during fetal development and during puberty, and is intracellularly regulated by cAMP levels. Defects in the CYP17A1 gene, which encodes for the protein, may cause adrenal hyperplasia type V (AH~V) which is characterized by hypokalemia and hypertension.Male patients affected by AH~V do not undergo normal sexual differentiation and develop female external genitalia and do not undergo pubertal develoment.

Specification
Aliases	Steroid 17~alpha~hydroxylase/17,20 lyase; 17~alpha~hydroxyprogesterone aldolase; CYPXVII; Cytochrome P450 17A1; Cytochrome P450~C17; Cytochrome P450c17; Steroid 17~alpha~monooxygenase; CYP17A1; CYP17; S17AH
Swissprot	P05093
clone	2H7E4
WB Predicted band size	~57kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human
Immunogen	Synthetic peptide, corresponding to amino acids 211~260 of Human CYP17A1.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2