Rabbit polyclonal antibody to HPK1 (L397)

Several mammalian kinases have been identified with sequence similarity to the Saccharomyces cerevisiae serine/threonine kinase STE20. STE20 is involved in relaying signals from G protein coupled receptors to cytosolic MAP kinase cascades, and it lies upstream of a MAP kinase kinase kinase. Mammalian STE20~like kinases include HPK1, KHS, GLK, NIK, YSK1, Krs~1, Krs~2 and GC kinase. HPK1 (hematopoietic progenitor kinase 1), like many other STE20~like kinases, specifically activates the JNK signaling pathway. HPK1 binds to and phosphorylates MEKK, suggesting it plays an important role in regulating the stress responsive JNK/SAPK signaling pathway.