Rabbit polyclonal antibody to DGK~δ (S66)

Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol (DAG) to produce phosphatidic acid. DAG and phosphatidic acid are lipids that act as second messengers in signaling cascades. DGK~α influences cell activation and secretion of lethal exosomes, which in turn control cell death. DGK~β is abundant in restricted brain regions such as the caudate putamen and olfactory tubercle. DGK~γ encodes full~length and truncated transcripts that are present in a range of human tissues, with greatest expression observed in retina. DGK~δ is most abundant in skeletal muscle. DGK~ε shows specificity for arachidonylcontaining diacylglycerol and is expressed predominantly in testis. DGK~θ is most abundant in the cerebellum and hippocampus. DGK~ι is present in brain and retina as a predominant transcript of more than 12 kb, including a long 3~prime untranslated region, with additional low abundance transcripts of 9.5 and 7.5 kb. DGK~η is closely related to DGK~δ. DGK~ζ is most abundant in brain and muscle. DGKs have structural motifs that play regulatory roles, and these motifs form the basis for dividing the DGKs into five subtypes.