Rabbit polyclonal antibody to LT~β (V211)

Tumor necrosis factor (TNF) and lymphotoxin~alpha (LT~α, also known as TNF−β) are members of a family of secreted and cell surface cytokines that participate in the regulation of immune and inflammatory responses. LT~β (lymphotaxin~beta or tumor necrosis factor C) is a type II membrane protein with significant homology to TNF, LT~α, and the ligand for the CD40 receptor. LT~α is present on the surface of activated T, B, and LAK cells as a complex with the 33 kda glycoprotein, LT~β. LT~β, also expressed by active lymphocytes, forms a heterotrimer with LT~a on the cell surface and anchors LT~α to the cell surface. A TNF receptor~related protein, the LT~β receptor (also known as TNFC receptor), is the human receptor for the LT~α/LT~β heterotrimer. There are two LT~β isoforms expressed in human lymphoid cell lines and non~Hodgkin's lymphomas. The gene which encodes LT~β maps to the major histocompatibility complex region on human chromosome 6p21.3.