Rabbit polyclonal antibody to HNF4α/γ (K127)

HNF~1 (α and β), HNF~3 (α, β and γ), HNF~4 (α and γ), and HNF~6 compose, in part, a homoeprotein family designated the Hepatocyte Nuclear Factor family. The various HNF~1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. HNF~3α, HNF~3β and HNF~3γ regulate the transcription of numerous hepatocyte genes in adult liver. HNF~3α and HNF~3β have also been shown to be involved in gastrulation events such as body axis formation. HNF~4α and HNF~4γ have been shown to be important for early embryo development. HNF~4α is expressed in liver, kidney, pancreas, small intestine, testis and colon; and HNF~4γ is expressed in each of these tissues except liver.