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Rabbit polyclonal antibody to FEN1 (A119)

Western blot (WB) analysis of FEN1 (A119) pAb at 1:500 dilution Lane1:SP2/0 whole cell lysate(20ug) Lane2:C6 whole cell lysate(40ug) Lane3:U~87MG whole cell lysate(40ug) Lane4:Hela whole cell lysate(40ug)

Rabbit polyclonal antibody to FEN1 (A119)

货号：
53519
别名：
Flap endonuclease 1; FEN~1; DNase IV; Flap structure~specific endonuclease 1; Maturation factor 1; MF1; hFEN~1; FEN1; RAD2
产品上架时间：
2024-01-01
应用：
WB IHC IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P39748
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1180

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Rabbit polyclonal antibody to FEN1 (A119)

Description
DNA replication, recombination and repair, all of which are necessary for genome stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. FEN~1 (for flap endonuclease) is an endonuclease that specifically cleaves the 5' flap structure of DNA in the process of DNA repair. FEN~1 is highly homologous to yeast Rad2. The C~terminal region of FEN~1 may bind to PCNA, thus allowing FEN~1 to function as an exonuclease in DNA replication.

Description

DNA replication, recombination and repair, all of which are necessary for genome stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. FEN~1 (for flap endonuclease) is an endonuclease that specifically cleaves the 5' flap structure of DNA in the process of DNA repair. FEN~1 is highly homologous to yeast Rad2. The C~terminal region of FEN~1 may bind to PCNA, thus allowing FEN~1 to function as an exonuclease in DNA replication.

Specification
Aliases	Flap endonuclease 1; FEN~1; DNase IV; Flap structure~specific endonuclease 1; Maturation factor 1; MF1; hFEN~1; FEN1; RAD2
Swissprot	P39748
clone	2H5A5
WB Predicted band size	~42kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide, corresponding to amino acids 100~150 of Human FEN1.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2