Rabbit polyclonal antibody to GRK5 (Q382)

Heterotrimeric G protein~mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist~mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messenger~regulated kinases, such as c~AMP dependent protein kinase A and protein kinase C. The second class includes the G protein~coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1), two forms of b~adrenergic receptor kinase: GRK 2 (bARK, bARK1) and GRK 3 (bARK2), IT~11 (GRK 4), GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist~activated state.