Rabbit polyclonal antibody to Cyclophilin F (Y121)

Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl~prolyl cis~trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Cyclophilin D (CyP40) is a widely expressed cytoplasmic protein that catalyzes the cis~trans isomerization of proline imidic peptide bonds in oligopeptides. Cyclophilin F (CyP3), is also known as PPIF, Cyp~D or Rotamase F, is a 207 amino acid mitochondrial matrix protein involved in the induction of necrotic and apoptotic cell death through the activation of the mitochondrial permeability transition (mPT) pore.