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Rabbit polyclonal antibody to ERCC5/XPG (E160)

Western blot (WB) analysis of ERCC5/XPG (E160) pAb at 1:1000 dilution Lane1:PC3 whole cell lysate(40ug) Lane2:SGC7901 whole cell lysate(20ug) Lane3:HCT116 whole cell lysate(20ug)

Rabbit polyclonal antibody to ERCC5/XPG (E160)

货号：
53509
别名：
COFS 3; COFS3; DNA excision repair protein ERCC 5; DNA excision repair protein ERCC~5; ERCC 5; ERCC5; ERCC5; ERCM 2; ERCM2; Excision Repair Cross Complementing Rodent Repair Deficiency; XPG; XPG complementing protein; XPGC;
产品上架时间：
2024-01-01
应用：
WB IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P28715
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to ERCC5/XPG (E160)

Description
Seven complementation groups (A~G) of xeroderma pigmentosum have been described. The xeroderma pigmentosum group A protein, XPA, is a zinc metalloprotein which preferentially binds to DNA damaged by ultraviolet (UV) radiation and chemical carcinogens. XPA is a DNA repair enzyme that has been shown to be required for the incision step of nucleotide excision repair. XPG (also designated ERCC5) is an endonuclease that makes the 3’ incision in DNA nucleotide excision repair. Mammalian XPG is similar in sequence to yeast RAD2. Conserved residues in the catalytic center of XPG are important for nuclease activity and function in nucleotide excision repair.

Description

Seven complementation groups (A~G) of xeroderma pigmentosum have been described. The xeroderma pigmentosum group A protein, XPA, is a zinc metalloprotein which preferentially binds to DNA damaged by ultraviolet (UV) radiation and chemical carcinogens. XPA is a DNA repair enzyme that has been shown to be required for the incision step of nucleotide excision repair. XPG (also designated ERCC5) is an endonuclease that makes the 3’ incision in DNA nucleotide excision repair. Mammalian XPG is similar in sequence to yeast RAD2. Conserved residues in the catalytic center of XPG are important for nuclease activity and function in nucleotide excision repair.

Specification
Aliases	COFS 3; COFS3; DNA excision repair protein ERCC 5; DNA excision repair protein ERCC~5; ERCC 5; ERCC5; ERCC5; ERCM 2; ERCM2; Excision Repair Cross Complementing Rodent Repair Deficiency; XPG; XPG complementing protein; XPGC;
Swissprot	P28715
clone	2G9F3
WB Predicted band size	~133,200kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human
Immunogen	Synthetic peptide, corresponding to amino acids 130~180 of Human ERCC5/XPG.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2