Rabbit polyclonal antibody to MZF~1 (D10)

Zinc finger genes encode metal~binding proteins are transcriptional regulators of other genes. Myeloid zinc finger 1 (MZF~1), also designated zinc finger protein 42, and transcription factor ZBP~89, also designated zinc finger protein 148, belong to the Krüppel C2H2~type zinc~finger protein family. The gene encoding for the MZF~1 protein maps to chromosome 19q13.43, while the gene encoding for ZBP~89 is localized on chromosome 3q21.2. These proteins are nuclear proteins involved in the regulation of transcriptional events. MZF~1 regulates transcription during hemopoietic development and plays a role in myeloid cell differentiation. It regulates the CD34 promoter in a tissue~specific manner. MZF~1 and FHL3 can form a complex of high molecular mass with other proteins in the nucleus. MZF~1 is induced by retinoic acid and is primarily expressed in differentiating myeloid cells.