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Rabbit polyclonal antibody to c~TAK1 (P8)

Western blot (WB) analysis of c~TAK1 (P8) pAb at 1:1000 dilution Lane1:Hela whole cell lysate(40ug) Lane2:HEK293T whole cell lysate(40ug) Lane3:C6 whole cell lysate(40ug) Lane4:CT26 whole cell lysate(40ug)

Rabbit polyclonal antibody to c~TAK1 (P8)

货号：
53506
别名：
C~TAK1; Cdc25C associated protein kinase 1; Cdc25C~associated protein kinase 1; cTAK1; ELKL motif kinase 2; EMK~2; Emk2; ETK 1; KIAA4230; KP78; MAP microtubule affinity regulating kinase 3; MAP/microtubule affinity~regulating kinase 3; Mark3; MARK3; Par 1a; PAR1A; Protein kinase STK10; Ser/Thr protein kinase PAR~1; Serine threonine protein kinase p78; Serine/threonine~protein kinase p78; SerThr protein kinase PAR 1; CTAK1
产品上架时间：
2024-01-01
应用：
WB IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P27448
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to c~TAK1 (P8)

Description
c~TAK1 (Cdc25C associated protein kinase) phosphorylates Cdc25C on Ser 216 and is ubiquitously expressed in various human tissue and cell lines. C~TAK1 is distinct from Chk1, which also phosphorylates Cdc25C on Ser 216 in response to DNA damage. Phosphorylation of Cdc25C allows for the preferential binding of 14~3~3 proteins, subsequently retaining Cdc25C in the cytoplasm. Thus, the binding of 14~3~3 proteins prevents Cdc25C from dephosphorylating Cdc2 in the nucleus, thereby controlling the entry of the cells into mitosis. It is suggested that C~TAK1 mediates the binding of the 14~3~3 proteins through its kinase activity and acts as a negative regulator of mitosis.

Description

c~TAK1 (Cdc25C associated protein kinase) phosphorylates Cdc25C on Ser 216 and is ubiquitously expressed in various human tissue and cell lines. C~TAK1 is distinct from Chk1, which also phosphorylates Cdc25C on Ser 216 in response to DNA damage. Phosphorylation of Cdc25C allows for the preferential binding of 14~3~3 proteins, subsequently retaining Cdc25C in the cytoplasm. Thus, the binding of 14~3~3 proteins prevents Cdc25C from dephosphorylating Cdc2 in the nucleus, thereby controlling the entry of the cells into mitosis. It is suggested that C~TAK1 mediates the binding of the 14~3~3 proteins through its kinase activity and acts as a negative regulator of mitosis.

Specification
Aliases	C~TAK1; Cdc25C associated protein kinase 1; Cdc25C~associated protein kinase 1; cTAK1; ELKL motif kinase 2; EMK~2; Emk2; ETK 1; KIAA4230; KP78; MAP microtubule affinity regulating kinase 3; MAP/microtubule affinity~regulating kinase 3; Mark3; MARK3; Par 1a; PAR1A; Protein kinase STK10; Ser/Thr protein kinase PAR~1; Serine threonine protein kinase p78; Serine/threonine~protein kinase p78; SerThr protein kinase PAR 1; CTAK1
Swissprot	P27448
clone	3A6H1
WB Predicted band size	~87kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide, corresponding to the N~terminal of Human c~TAK1.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2