Rabbit polyclonal antibody to NF~YB (Q30)

The CCAAT~binding factor NF~Y is a heteromeric transcription factor that specifically binds to CCAAT sequences in many eukaryotic genes. NF~Y is made up of three subunits, NF~YA, NF~YB and NF~YC. All three components are necessary for DNA binding. In each NF~Y subunit, the segment needed for formation of the NF~Y~DNA complex is conserved from yeast to human. These conserved segments are homologous to the histone~fold motif of eukaryotic histones. The DNA~binding domains of the NF~YB and NF~YC subunits have been suggested to interact through a protein~protein, histone~fold “handshake” motif in a manner analogous to the histone proteins H2B and H2A, respectively.