Rabbit polyclonal antibody to ARP~1 (T7)

COUP (chicken ovalbumin upstream promoter) transcription factors have been cloned in several species and identified as orphan members of the steroid/thyroid hormone receptor superfamily. COUP~TFI (also designated COUP or EAR~3) and ARP~1 (also designated COUP~TFII) exhibit highly regulated and overlapping expression in most tissues. COUP~TFs are highly expressed in the developing and central nervous system, suggesting that these factors may be important in neural development and differentiation. COUP~TFs can compete for binding to response elements which are common to other members of this family, including RAR, RXR, PPAR, HNF~4, VDR and TR. They have been shown to act as negative regulators as well as initiators of transcription.