Rabbit polyclonal antibody to DGK~α (A340)

Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol (DAG) to produce phosphatidic acid. DAG and phosphatidic acid are lipids that act as second messengers in signaling cascades. DGK~alpha influences cell activation and secretion of lethal exosomes, which in turn control cell death. DGK~beta is abundant in restricted brain regions such as the caudate putamen and olfactory tubercle. DGK~gamma encodes full~length and truncated transcripts that are present in a range of human tissues, with greatest expression observed in retina. DGK~delta is most abundant in skeletal muscle. DGK~epsilon shows specificity for arachidonyl~containing diacylglycerol and is expressed predominantly in testis. DGK~zeta is most abundant in brain and muscle. DGK~eta is closely related to DGK~delta. DGK~theta is most abundant in the cerebellum and hippocampus.