Rabbit polyclonal antibody to Myf~6 (R150)

Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix~loop~helix (HLH) proteins known to play an important role in the regulation of muscle cell development includes Myo D, myogenin, Myf~5 and Myf~6 (also designated MRF~4 or herculin). Most muscle cells express either Myo D or Myf~5 in the committed state, but when induced to differentiate, all turn on expression of myogenin. Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D~E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle~specific terminal differentiation genes.